ALS/MND

ALS (Amyotrophic lateral sclerosis)/MND is a kind of irreversible deadly motor neuron disease (MND). This kind of degenerative disease occurred in motor nerve cells. Its progression can be very fast and leads to gradual decrease of motor nerve cells, gradual increase of amyotrophy and muscle weakness until complete paralyses. The disease also affects lung functions and results in respiratory failure eventually.

Although ALS/MND is a very serious disease, we can't give up hope in fighting it. Patients should get diagnosed as soon as possible for comprehensive treatment in the earliest possible stage. With the progress of science and technology, many patients can obtain good improvement. Through proper treatment, the quality of life can be significantly improved and the lifespan of a patient can be prolonged. Dr. Wu and his team have also done a lot of research on the disease and are willing to help the patients gain more knowledge about it. If you have any questions/concerns, please contact us. Let's fight  ALS/MND together.）

Ataxia

Ataxia is a form of movement disorder. Patients with Ataxia experience a loss of balance and physical co-ordination, leading to difficulty walking normally. The cerebellum of the brain is normally responsible for maintaining balance and co-ordination. Ataxia occurs when there is damage to the cerebellum. It may also result from damage to other parts of the nervous system.

Eye Disorders

1. Retinal abnormality
2. Macular Degeneration
3. Optic Neuropathy (Atrophy)

Retinopathy of Prematurity (ROP)

The retinopathy of prematurity (ROP) is because of prematurity, low weight when the patient is born and long time hypoxia which results in retinal fibrovascular hyperplasia or contraction, then leads to the tractional detachment of the retina, retrolental fibroplasia and blindness.

Parkinson's Disease

Parkinson's disease (PD) is a degenerative disorder of the central nervous system, PD is more commonly seen in the elderly. With most cases occurring after the age of 60, the sickness rate after the age of 65 is about 2%. Most cases are sporadic, less than 10% of the patients have family history of the disease.

Multiple Sclerosis (MS)

MS is an autoimmune disease in which immune cells attack and destroy the protective myelin sheaths that surround nerve fibres, leading to neurological disturbances. With the disease’s repetitive recurrence or continuous progression, resulting in central nerve axons damage and nerve necrosis, patients would present sequela conditions of central nerve necrosis, including limbs’s paralysis, balance disturbance, etc.

Multiple System Atrophy (MSA)

MSA is a kind of neurological condition where multiple cerebral nerve tissues have gotten affected, including the cerebellum (resulting in balance disturbance), vegetable nerve system (resulting in Orthostatic Hypotension, urinary function disturbance, heart function disturbance), brain stem and basal ganglia (resulting in Parkinson-like symptoms, limbs rigidity). The cerebral cortex would get affected at relatively later stage, resulting in cognitive function decline. It is a progressive disease. Cerebral atrophy can be observed in image at middle-late stage.

Muscular Dystrophy

Muscular Dystrophy(MD) is a group of muscle degenerative diseases related to heredity. Due to DNA mutations in muscle cells, resulting in gradual decrease of muscle cells, patients present muscle weakness and muscle atrophy, which would progress gradually, finally leading to total paralysis. It is a kind of progressive disease.

Charcot Marie Tooth Disease

CMT is hereditary peripheral nerve degenerative disease. Due to DNA mutations of peripheral motor nerves and sensory nerves, which results in axonal and myelin sheath damage, patients present nerve function loss, distal muscle weakness of limbs, muscle atrophy, accompanied by feet deformity, ankle joint deformity, and sensory disturbance. At late stage, the disease can progress very fast, resulting in total paralysis. It is a progressive disease.

CIDP

Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immune-mediated inflammatory disorder of the peripheral nervous system. It is considered an autoimmune disorder destroying myelin, the protective covering of the nerves. Typical early symptoms are "tingling" (sort of electrified vibration or paresthesia) or numbness in the extremities, frequent (night) leg cramps, loss of reflexes (in knees), muscle fasciculations, "vibration" feelings, loss of balance, general muscle cramping and nerve pain. It is a kind of progressive disease, and would lead to total paralysis in the end.

Cerebral Palsy

Cerebral palsy is a group of disorders that can involve brain and nervous system functions, such as movement, learning, hearing, seeing, and thinking. Cerebral palsy is caused by injuries or abnormalities of the brain. Most of these problems occur as the baby grows in the womb. But they can happen at any time during the first 2 years of life

Spinal Cord Injury

A spinal cord injury has the closest relationship with the paralysis syndrome, which is caused by ischemia or hemorrhaging of the spinal cord, the rapidly progressive compression, necrosis, demyelination, or myelitis. A pressure or cut on the spinal cord can cause damage of gray matter in the spinal cord nerve cells. The white matter nerve fiber and the different amounts of hemorrhaging, where the most severe is in the center of the vessel, the parts of the damaged area become gelatinous liquefactive cavities or ferrite liquefactive cavities. These can become a progressive fibrosis or/and cavity in the brain or/and the membrane of the spinal cord after months or years time. Parts of the damaged area can become the delayed central cord syndrome.
Brain Injury

Dementia

Dementia is the most important and most common degenerative brain disease. Cerebral atrophy that progresses for many years, and severe brain atrophy and dementia are clinically difference from the atrophy that occurs normally with aging. The late pathologic change in patients who have dementia has been confirmed as the appearance of atrophy diffusion in the brain, and the weight of the brain is usually reduced by at least 20%. In addition, the gyrus becomes narrower and the sulci become wider. The symmetry of the third ventricle and lateral ventricle changes and they have different degrees of expansion. Microscopically, a large number of the nerve cells are lost, especially in the cerebral cortex, and the nuclei in the brain also lose nerve cells, especially in monoamine nervous system in the stem of the brain. The decrease in the number of cholinergic neurons in basal ganglia may affect memory.

The clinical manifestations of dementia include: the existence of a variety of mental disorders including personality change, inability to remember how to perform simple tasks like use household items or tools, while still retaining the ability to complete the action; inability to use a pen, razor, tableware, or unlock something. These actions are not ideational apraxia.
The most common dyspraxia are the inability to walk stably or with large steps. Towards the end of disease, certain reflexes are difficult to perform, such as grasping and sucking, and there are other signs of the frontal diseases, urinary and fecal incontinence. Patients that remain silent will eventually lose his or her ability to walk and may become paralyzed, with a complete inability to care for his- or herself.

Epilepsy

Epilepsy is a neurological condition, which affects the nervous system. Epilepsy is also known as a seizure disorder. It is usually diagnosed after a person has had at least two seizures that were not caused by some known medical condition like alcohol withdrawal or extremely low blood sugar.  Sometimes, according to the International League Against Epilepsy, epilepsy can be diagnosed after one seizure, if a person has a condition that places them at high risk for having another.

The seizures in epilepsy may be related to a brain injury or a family tendency, but most of the time the cause is unknown. The word "epilepsy" does not indicate anything about the cause of the person's seizures, what type they are, or how severe they are. It results from the generation of electrical signals that come from inside the brain, causing recurring seizures. Seizure symptoms vary from one person to another. Some people suffering from epilepsy simply stare blankly for a number of seconds while undergoing a seizure. Others have full-fledged convulsions.